Mood & Mental Health

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Study

One Psilocybin Dose Lowered Neuroticism in Healthy Volunteers

One Psilocybin Dose Lowered Neuroticism in Healthy Volunteers

Psilocybin mushrooms

What they found

A single 25mg psilocybin dose reduced neuroticism in healthy volunteers one month later, unlike a 1mg control.

A single 25mg psilocybin dose reduced neuroticism in healthy volunteers one month later, unlike a 1mg control.

The number

single 25mg dose

How solid is it?

Early human

Early human

Human – RCT

Human – RCT

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Lowering Neuroticism

Lowering Neuroticism

A single 25mg dose of psilocybin reduced neuroticism in healthy volunteers after one month, unlike a 1mg control dose. Changes were strongest in those who found the experience meaningful or felt ego dissolution anxiety.

A single 25mg dose of psilocybin reduced neuroticism in healthy volunteers after one month, unlike a 1mg control dose. Changes were strongest in those who found the experience meaningful or felt ego dissolution anxiety.

🕯️ Alzheimer’s Hope, Gut Health Boosters, and Mushrooms vs. Obesity

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