Another new study evaluated the effectiveness of psychedelics versus escitalopram (Lexapro) for depressive symptoms, finding that only high-dose psilocybin was significantly more effective than escitalopram, while low-dose psychedelics and MDMA were less effective. Psilocybin had a 6.45-point better result than placebos in antidepressant trials and outperformed Lexapro at both 10 mg and 20 mg doses, using a specific depression rating scale (the 17-item Hamilton Depression Rating Scale).