A comparative HNBGU study of oyster mushroom proteins against cavities revealed both promise and limitations. While cultivated variety showed 90% pathogen killing in dental bacteria within 4 hours and wild type achieved superior plaque biofilm prevention, practical challenges emerged. Commercial scaling remained difficult - even though wild mushrooms showed better cavity-protective effects, their limited availability poses barriers, with researchers noting "using cultivated variety as primary component" may be necessary despite reduced potency against tooth decay.