Pain & Headache

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Review

Psilocybin Cuts Migraine and Cluster Headache Frequency

Psilocybin Cuts Migraine and Cluster Headache Frequency

Psilocybin mushrooms

What they found

Clinical trials found psilocybin reduced migraine and cluster headache frequency even without strong psychedelic effects.

Clinical trials found psilocybin reduced migraine and cluster headache frequency even without strong psychedelic effects.

How solid is it?

Review

Review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Neurology

Neurology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Headache Relief

Headache Relief

Psilocybin reduced migraine and cluster headache frequency in clinical trials, even without producing strong psychedelic effects. The changes weren’t tied to mental health or trip intensity, suggesting psilocybin may ease pain through a direct neurological mechanism.

Psilocybin reduced migraine and cluster headache frequency in clinical trials, even without producing strong psychedelic effects. The changes weren’t tied to mental health or trip intensity, suggesting psilocybin may ease pain through a direct neurological mechanism.

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