Pain & Headache

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Study

Psilocybin Eases Chronic Nerve Pain in Mice for Up to 14 Days

Psilocybin Eases Chronic Nerve Pain in Mice for Up to 14 Days

Psilocybin mushrooms

What they found

Psilocybin reduced nerve-damage and inflammatory pain sensitivity in mice for up to 14 days.

Psilocybin reduced nerve-damage and inflammatory pain sensitivity in mice for up to 14 days.

The number

up to 14 days

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Pharmacological Research

Pharmacological Research

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Chronic Pain Relief

Chronic Pain Relief

Psilocybin may help relieve chronic pain by activating 5-HT2A receptors, which play a role in pain perception. In mouse models, psilocybin reduced sensitivity to pain caused by nerve damage and inflammation, with effects lasting up to 14 days —far longer than conventional treatments.

Psilocybin may help relieve chronic pain by activating 5-HT2A receptors, which play a role in pain perception. In mouse models, psilocybin reduced sensitivity to pain caused by nerve damage and inflammation, with effects lasting up to 14 days —far longer than conventional treatments.

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