Mood & Mental Health

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Study

Psilocybin for Anorexia Shows Promise and Limits in Pilot

Psilocybin for Anorexia Shows Promise and Limits in Pilot

Psilocybin mushrooms

What they found

In a Phase 1 pilot, 4 of 10 anorexia patients reached clinical remission at 3 months after 25mg psilocybin.

In a Phase 1 pilot, 4 of 10 anorexia patients reached clinical remission at 3 months after 25mg psilocybin.

The number

4/10 patients achieved clinical remission at 3 months

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

10 patients

10 patients

Published in

Psychedelics (Genomic Press)

Psychedelics (Genomic Press)

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Mixed Results in Anorexia Treatment

Mixed Results in Anorexia Treatment

A Phase 1 UCSD pilot study of psilocybin therapy (25mg) revealed both promise and limitations. While 90% rated it a top-5 life experience and 4/10 patients achieved clinical remission at 3 months, significant challenges emerged. Weight restoration remained difficult - even patients who felt mentally recovered struggled with food behaviors, noting "restoring weight requires effort" despite reduced anxiety.

A Phase 1 UCSD pilot study of psilocybin therapy (25mg) revealed both promise and limitations. While 90% rated it a top-5 life experience and 4/10 patients achieved clinical remission at 3 months, significant challenges emerged. Weight restoration remained difficult - even patients who felt mentally recovered struggled with food behaviors, noting "restoring weight requires effort" despite reduced anxiety.

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