Mood & Mental Health

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Study

Psychedelic Therapy Cut Depression Scores 29% in Small Study

Psychedelic Therapy Cut Depression Scores 29% in Small Study

Psilocybin mushrooms

What they found

Among 28 patients given psychedelic therapy, depression scores fell 29% and stayed lower at follow-up.

Among 28 patients given psychedelic therapy, depression scores fell 29% and stayed lower at follow-up.

The number

29% reduction in depression scores

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

28 patients and 28 healthy volunteers

28 patients and 28 healthy volunteers

Published in

Journal of Psychopharmacology

Journal of Psychopharmacology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

More Data for Depression

More Data for Depression

This open-source study compared 28 patients receiving psychedelic therapy with 28 healthy volunteers found a 29% reduction in depression scores that persisted at follow-up. While patients experienced 40% less ego dissolution than controls, real-time relaxation scores were the strongest predictor of antidepressant response. 93.5% of patients reported mild side effects that resolved within 48 hours.

This open-source study compared 28 patients receiving psychedelic therapy with 28 healthy volunteers found a 29% reduction in depression scores that persisted at follow-up. While patients experienced 40% less ego dissolution than controls, real-time relaxation scores were the strongest predictor of antidepressant response. 93.5% of patients reported mild side effects that resolved within 48 hours.

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