Mood & Mental Health

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Review

Psilocybin Matches Ketamine for Major Depression in Trial Review

Psilocybin Matches Ketamine for Major Depression in Trial Review

Psilocybin mushrooms

What they found

A review of 28 clinical trials found psilocybin as effective as IV ketamine and better than theta burst stimulation for major depression.

A review of 28 clinical trials found psilocybin as effective as IV ketamine and better than theta burst stimulation for major depression.

The number

A review of 28 clinical trials

How solid is it?

Strong human

Strong human

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

231 psilocybin participants

231 psilocybin participants

Published in

PCN Reports : Psychiatry and Clinical Neurosciences

PCN Reports : Psychiatry and Clinical Neurosciences

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Psilocybin, Ketamine, and TBS

Psilocybin, Ketamine, and TBS

A review of 28 clinical trials found that psilocybin therapy is as effective as IV ketamine and better than theta burst stimulation (TBS) for major depression. Analyzing 231 psilocybin participants, researchers found lasting benefits at 4+ weeks, with depression scores improving significantly more than TBS.

A review of 28 clinical trials found that psilocybin therapy is as effective as IV ketamine and better than theta burst stimulation (TBS) for major depression. Analyzing 231 psilocybin participants, researchers found lasting benefits at 4+ weeks, with depression scores improving significantly more than TBS.

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