Brain & Cognition

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Study

Psilocybin Strengthens Brain-Wide Connectivity in Rats

Psilocybin Strengthens Brain-Wide Connectivity in Rats

Psilocybin mushrooms

What they found

MRI in awake rats showed psilocybin increased brain activity and connectivity, with females more sensitive at 0.3 mg/kg.

MRI in awake rats showed psilocybin increased brain activity and connectivity, with females more sensitive at 0.3 mg/kg.

The number

0.3 mg/kg

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

bioRxiv

bioRxiv

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Neural Communication

Neural Communication

MRI scans in awake rats showed dose-dependent increases in brain activity, especially in sensory and motor regions. At 0.3 mg/kg, females were more sensitive than males. Psilocybin also strengthened brain-wide connectivity, particularly with the cerebellum, highlighting its potential to enhance neural communication.

MRI scans in awake rats showed dose-dependent increases in brain activity, especially in sensory and motor regions. At 0.3 mg/kg, females were more sensitive than males. Psilocybin also strengthened brain-wide connectivity, particularly with the cerebellum, highlighting its potential to enhance neural communication.

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