This systematic review looked at how clinical trials of psilocybin-assisted psychotherapy report side effects. Most trials did report adverse events, but the level of detail and consistency varied widely. Common effects included nausea, transient anxiety, and headache, while serious events were rare. The review highlights that better, more standardized safety reporting is needed so patients, clinicians, and the public can clearly understand what to expect, how common side effects are, and how they’re managed in therapeutic settings.