Cancer

·

Study

Reishi-Relative Protein Kills Cancer Cells but Spares Normal Cells

Reishi-Relative Protein Kills Cancer Cells but Spares Normal Cells

Reishi relative

What they found

FIP-Gre protein from Ganoderma resinaceum killed lung, liver and breast cancer cells without harming normal cells in lab tests.

FIP-Gre protein from Ganoderma resinaceum killed lung, liver and breast cancer cells without harming normal cells in lab tests.

The number

21.27 µg/mL (lung)

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Ganoderma resinaceum

Ganoderma resinaceum

Compound

FIP-Gre

FIP-Gre

Published in

Molecular Biology Reports

Molecular Biology Reports

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Targeted Tumor Shutdown

Targeted Tumor Shutdown

Reishi relative (Ganoderma resinaceum) protein FIP-Gre selectively killed cancer cells with IC₅₀ values of 21.27 µg/mL (lung), 29.96 µg/mL (liver), and 43.34 µg/mL (breast), while showing no toxicity to normal cells. At just 8 µg/mL, it triggered cancer cell death by increasing pro-apoptotic signals and also showed strong binding to cancer-driving receptors EGFR and c-Met, directly blocking tumor growth pathways.

Reishi relative (Ganoderma resinaceum) protein FIP-Gre selectively killed cancer cells with IC₅₀ values of 21.27 µg/mL (lung), 29.96 µg/mL (liver), and 43.34 µg/mL (breast), while showing no toxicity to normal cells. At just 8 µg/mL, it triggered cancer cell death by increasing pro-apoptotic signals and also showed strong binding to cancer-driving receptors EGFR and c-Met, directly blocking tumor growth pathways.

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