Brain & Cognition

·

Study

Review of 81 Brain Imaging Studies Shows How Psilocybin Works

Review of 81 Brain Imaging Studies Shows How Psilocybin Works

Psilocybin mushrooms

What they found

A review of 81 human neuroimaging studies found psilocybin disrupts rigid brain networks and boosts neural flexibility.

A review of 81 human neuroimaging studies found psilocybin disrupts rigid brain networks and boosts neural flexibility.

The number

81 human neuroimaging studies

How solid is it?

Strong human

Strong human

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

81 studies

81 studies

Published in

Neuroscience & Biobehavioral Reviews

Neuroscience & Biobehavioral Reviews

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Inside the Psilocybin Brain

Inside the Psilocybin Brain

This sweeping review of 81 human neuroimaging studies shows how psilocybin changes the brain: it disrupts rigid networks like the default mode network, boosts neural flexibility, and rewires how we process emotion, memory, and self-awareness. Effects are both immediate and long-lasting—offering insight into how psilocybin supports lasting improvements in mood, addiction, and cognition.

This sweeping review of 81 human neuroimaging studies shows how psilocybin changes the brain: it disrupts rigid networks like the default mode network, boosts neural flexibility, and rewires how we process emotion, memory, and self-awareness. Effects are both immediate and long-lasting—offering insight into how psilocybin supports lasting improvements in mood, addiction, and cognition.

Psilocybin for Awe, Mycelium vs. Oil, and a Supplement Wake-Up Call

Read the original study ↗

Get Shroom Scan

Next study

Psilocybin Microdoses May Extend Cluster Headache Remission ›

Shroom Scan · Every Friday

Get Studies Like This, Translated, Every Week

Ten new studies a week, each boiled down to what it found and why it matters to you. Free, and one click to leave.

See what's inside →