Mood & Mental Health

·

Study

Single 25 mg Psilocybin Dose Kept Depression Away for 189 Days

Single 25 mg Psilocybin Dose Kept Depression Away for 189 Days

Psilocybin mushrooms

What they found

In treatment-resistant depression, a single 25 mg psilocybin dose maintained antidepressant effects for 189 days vs. 43 days at 10 mg.

In treatment-resistant depression, a single 25 mg psilocybin dose maintained antidepressant effects for 189 days vs. 43 days at 10 mg.

The number

maintained antidepressant effects for 189 days

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

The Journal of Clinical Psychiatry

The Journal of Clinical Psychiatry

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Long-Term Effects

Long-Term Effects

A 52-week follow-up of treatment-resistant depression patients found that a single 25 mg dose of psilocybin maintained antidepressant effects for 189 days, compared to 43 days (10 mg) and 21 days (1 mg). Most participants relapsed by Week 12, but higher doses showed longer-lasting benefits.

A 52-week follow-up of treatment-resistant depression patients found that a single 25 mg dose of psilocybin maintained antidepressant effects for 189 days, compared to 43 days (10 mg) and 21 days (1 mg). Most participants relapsed by Week 12, but higher doses showed longer-lasting benefits.

Flu Defense, Joint Health, and Psilocybin’s Metabolic Edge

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