Pain & Headache

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Study

Single Psilocybin Dose Cut Migraine Days by About Half

Single Psilocybin Dose Cut Migraine Days by About Half

Psilocybin mushrooms

What they found

In a randomized double-blind trial of 18 adults, 10 mg psilocybin cut migraine days by roughly 50%.

In a randomized double-blind trial of 18 adults, 10 mg psilocybin cut migraine days by roughly 50%.

The number

80% of people who received psilocybin (one or two doses) achieved at least a 50% reduction

How solid is it?

Early human

Early human

Human – RCT

Human – RCT

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

18 adults

18 adults

Published in

Headache: The Journal of Head and Face Pain

Headache: The Journal of Head and Face Pain

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Migraine Relief

Migraine Relief

In a randomized, double-blind trial of 18 adults with frequent migraines, a single 10 mg dose of psilocybin or two doses given one week apart both reduced migraine days by roughly 50%, similar to earlier findings. Over the first two weeks, 80% of people who received psilocybin (one or two doses) achieved at least a 50% reduction in migraine frequency, compared with 17% in the active placebo group, although results did not reach statistical significance due to the small sample size. No serious adverse events occurred.

In a randomized, double-blind trial of 18 adults with frequent migraines, a single 10 mg dose of psilocybin or two doses given one week apart both reduced migraine days by roughly 50%, similar to earlier findings. Over the first two weeks, 80% of people who received psilocybin (one or two doses) achieved at least a 50% reduction in migraine frequency, compared with 17% in the active placebo group, although results did not reach statistical significance due to the small sample size. No serious adverse events occurred.

Psilocybin Cuts Migraines, Gut Fungi Signal Mental Health

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