Cancer

·

Study

Turkey Tail and Enoki Compounds May Target HER2 Breast Cancer

Turkey Tail and Enoki Compounds May Target HER2 Breast Cancer

Turkey tail, Enoki

What they found

Turkey tail and enoki compounds bound tightly to HER2 in computer models, and turkey tail blocked 62.5% of inflammation-related protein breakdown in lab tests.

Turkey tail and enoki compounds bound tightly to HER2 in computer models, and turkey tail blocked 62.5% of inflammation-related protein breakdown in lab tests.

The number

blocked 62.5% of inflammation-related protein breakdown at 500 µg/mL

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Trametes versicolor, Flammulina velutipes

Trametes versicolor, Flammulina velutipes

Published in

Biochemistry and Biophysics Reports

Biochemistry and Biophysics Reports

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Breast Cancer Target

Breast Cancer Target

Compounds in turkey tail (Trametes versicolor) and enoki (Flammulina velutipes) may help interfere with HER2, a protein that drives 15–20% of aggressive breast cancers. Enoki reduced inflammatory protein damage with strong activity at 2.86 µg/mL, while turkey tail blocked 62.5% of inflammation-related protein breakdown at 500 µg/mL. Natural compounds in the mushrooms bound tightly to the HER2 protein (−5.88 to −5.24 kcal/mol), similar to the chemotherapy drug doxorubicin (−5.43 kcal/mol).

Compounds in turkey tail (Trametes versicolor) and enoki (Flammulina velutipes) may help interfere with HER2, a protein that drives 15–20% of aggressive breast cancers. Enoki reduced inflammatory protein damage with strong activity at 2.86 µg/mL, while turkey tail blocked 62.5% of inflammation-related protein breakdown at 500 µg/mL. Natural compounds in the mushrooms bound tightly to the HER2 protein (−5.88 to −5.24 kcal/mol), similar to the chemotherapy drug doxorubicin (−5.43 kcal/mol).

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